Funnily enough, only NPCs I find myself disliking so far are... well, a few of the random repeatable encounters that I just don't like and end up finding more than half of my grind in any area; the Old Forest has that Wyld Elf I just can't bring myself to get used to but he shows up more often than any other random script in the area.
The Frostwood has Kurako - which is a nice initial few encounters ar first - but then it's just a lot of "Oh don't mind me, just secretly stalking you but not really (just kidding I'm stalking you)" (but the headpats scene is still nice every so often).
Foothills? Byvernia still upsets me for now until some more content comes in for her, which is likely only if/when PC gets some dragon/wyvern TFs or somehow a wyvern companion wedges themselves in, which is much X to doubt.
Harvest Valley for me is the lupine duo that... also doesn't have much content, if any, that I can find - they hunt for their tribe, but where is their tribe? And all those hip quivers... Same with the cultists still showing up even after doing the Centaur village quest - how do the same three cultistd have all those Charms?
The Rift only bugs me because that chimera do be looking hot and I can't slap a collar on her. Yet. Maybe. Hopefully.
If Evergreen did all that stuff that people talk about recently in the thread, why do the two sisters stick around still? Or all those other kids that mess around?