Granted, a lot of those factors are mutable though you still can't see it all on one run without save scumming, which was my main point. This is not a game where you can do 100% completion on a straight-line progression from beginning to end and it never has been. You're going to miss content no matter what and there's only so much hand-holding that's reasonable. Consider the following cases of much more substantial content-gating that the devs did not think needed explicit warnings:
Whether you have Brint or Brienne is perhaps the most obvious example, and that's really substantial content. The devs didn't feel the need to explicitly lay out what the implications for future content were going to be prior to making that choice, even though. it almost completely changes the interactions the character has with everybody, has mutually exclusive gear sets and basically has a whole lot of content-gating whichever way you go. Yes, we know the implications because they've been in the game for a long time but the game does not lay out for you exactly what you're opting in to/out of.
Or for another example, deciding to push Azzy and Lia into the corrupted honey because you felt like being Stupid Evil and then you realize later that you've enfuckened yourself for the Dawnsword quest and can't see a huge chunk of content unless you unwind your run. The game doesn't explicitly warn you about that either, it just warns you that you can't undo this. Y'know, like the warning you already get when you try to sell something Unique.
For a lesser example, sex before encountering Evelyn can permanently lock you out of her scenes that check for the Champ's v-cards. Should the devs include a warning before every possible sex scene that you might lock yourself out of future content by having sex prior to meeting a character you haven't even encountered yet?
Yes, I recognize that I'm veering towards a slippery slope argument here, but given the amount of things you can already lock yourself out of in a single run (or which require forked saves to handle) that are far more substantial than some minor dialogue changes for Hethia and which the game doesn't explicitly hold your hand and warn you about, I'm not sure that adding warnings that a given item might have content down the line is really a good use of time, especially since the perennial example of the Hornet Ring demonstrates that many players don't read warnings in the first place.
