So, the way I resolve the inconsistencies is to assume that the typical transformative actually does change the person's genes, but most people's immune boosters specifically preserve the reproductive cells as they originally were. Occasionally a change slips through, which means if a large population takes the same mods consistently across multiple generations it eventually sticks. The huskar have been doing this intentionally to preserve their adaptations, the New Texans have been semi-unintentionally doing the same with the Treatment as of at least Reaha's generation.