I would love a mission that takes advantage of PCs mutation and morphing abilities like. Sorry only women from this point and then switch back to male to change identity. Or sorry only people this tall or short can get through this area and PC can be anything so why not take full advantage of that?
I like the thought (and I am not poo-pooing the idea), I just think that, functionally, it would be troublesome for players that like their Champ's form (and some work really hard getting it just right) especially when some qualities are random, or trying to figure out what herbs or concoctions they need to find to do the specific thing (looking things up on wiki), and then buying or potentially gathering them. And then returning to their preferred form after.
I like the idea of such areas, but I think there would have to be a bypass (longer route or more enemies to fight) or other challenge to be done instead (have wings, can fly up ledge, don't have wings, have to climb and need a check or fall and take damage). A short passage that a Champ under 5-feet can get through that shaves off 5 tiles, sure... but then you also need to explain why Brint or Brienne are just following along (or not let Champ take the shortcut without smaller companions too).
So it's doable, just seems like it wouldn't be as well-loved or appreciated.