By all accounts, Tychris is itself an area that the story isn't going to require you to visit, just as the floofhaus is a huge chunk of content that is completely optional if you're just following the main plot. I have to imagine most players will want to see Tychris but it's one of those adjacent areas like the Glacial Rift that you can go to if you want to but you don't need to.Im looking at the planned zones post and, while the centaur stuff itself is optional, it feels like the area itself is technically not optional considering how its probably gonna be the only way to tychis and is the only way to the city of beef.
Harvest Valley likewise is an area that you don't have to visit to progress In Her Footsteps. While completing its big quest is a part of unlocking the Champion of Hawkethorne title and several other quests with major content (like Mad Cow, which is essential if you want to turn Brint into Brienne) it's not needed to get into Khor'minos. You can get peaceful access to the Undermountain zone after clearing the Winter City or you can fight your way in whenever you're feeling brave enough. Harvest Valley has naught to do with it.
Oh? Anything you're willing to share at this point?This is one of the few times when primordial plans have actually changed somewhat.