Of course! Personally, I'm itching for a non-Vanilla RP myself. So we're in the same boat.
To me, it sounds like you want the best of both CoC and TiT's worlds without succumbing to the limitations of either one. Something I very much like.
As for a workable plot:
We could take a page out of TiT's book and be a pair of intergalactic explorers way in over our heads. You could get us tied in with some off-world plot being headed by some mega-corporation and the like.
Or have us be part of a part of a *guild* of mercenaries explorers/adventurers/explorers venturing off to unknown regions/battlefields in search of fame and fortune. Whether in space or just on a specific planet. Your choice.
If in space, I have an idea for the main ship our characters could stay on. It's based on a ship from of my favorite PS2 RPG's:
(Yes, believe it or not this thing actually flies in space and you can step out on to the deck while in said space. Magitek at its finest.
)
Complete with its own bridge, tavern, and private quarters for our characters.
But then again, this could very well double as an airship, too, depending on the tech-level you want this RP in.