The first thing Isabel's gonna do after she becomes CEO is launch a Spanish Inquisition against her own company - particularly the Board of Directors - to see who hasn't been keeping up Steele Tech's high moral standards since Victor's death, and dole out punishments (and referrals to any relevant courts for criminal charges, if necessary) as appropriate. Once that's done and any Board members thusly fired have been replaced, it'll be business as usual, but with several major changes: one, trying to expand the relatively recent additions to the company (i.e. Applied Sciences and the entertainment division Bizzy started); two, trying to take down Carver, Pyrite, SagiTom and other particularly unethical megacorps; three, trying to take down Brightwater, consolidate control over Utopian Skies (and thus Dhaal as a whole, which may require taking them down, too) and massively raise the standards of just about everything on Dhaal; four, general philanthropic endeavours, including lobbying for greater protections for indentured servants. She'll also try to help resolve the war on Myrellion peacefully, if she can and that hasn't been resolved yet.
On her personal life's side, she'll almost certainly marry several of her lovers, significantly slow down the rate at which she acquires more lovers and children, and try to fit in being a good lover and mother to her lovers and children (respectively) to her no doubt busy CEO schedule. And again, philanthropic endeavours, these ones being paid for out of her own deep pockets.