Some perks are incredible, while most are so bad that even if they were to be buffed ten times, I'd still have to consider if I'd want to take them because of their intentionally situational design that sound like they were made for a different game entirely. Perks that do affect dialogue only have a handful instances to them (most have none at all and some only have one or two during the DLCs) all of which are either entirely flavor or are of questionable practicality, not to mention that most of them should've been reworked as traits. SPECIAL checks, dialogue or exploration, are similarly few, far in-between and are easily bypassed through common and generally weightless consumables, even if starting from the bottom score of 1.
Between re-introducing the energy-to-matter conversion, but a lot more sophisticated and largely disregarded as a curiosity by everyone, including the insane tech guy a lot of the game was propping up as a genius, putting a vault of space-age tech and the scientists that made and are slated to make more of it without any supporting infrastructure in the Courier's hands and then promptly forgetting all about its existence, the poisonous cloud that will eventually kill everyone and the funny mole people that will eventually kill everyone, the world design of Fallout had suffered greatly from Avellone's DLCs, to the extent that not even Fallout 4 dared approach.
Is so irrelevant I've actually forgot about it. The system is used only once or twice for the NCR/Legion outside of giving you stuff and making nameless NPCs talk nicer to you, while everyone else has no such privilege. BoS faction can't be maxed out without finishing the worst DLC in the game in one specific way, Primm had its faction cut and more deserving towns had no faction at all. Only one faction, a major one and the most controversial one at that, out of them all actually gives something unique and possibly vital for some builds with its reputation. I honestly feel that if (and it really should've been; everyone giving you keys to far-away safehouses that have exactly three loadouts for different builds with different themes per faction splayed out on beds feels so incredibly uniformal and soulless that it should be taken as an insult) this system were to be cut, nobody would've missed it.
Are nothing noteworthy as they are, let alone with the whole Ulysses' series almost entirely setting your character's background for you.