The race calculator says I'm human but I've save edited in enough peripheral TF's that it likely wouldn't appear that way. I imagine that's what Victor Steele did before the beginning of the game except without god modding and the microsurgeons so he died of taint.
I always do Human+ builds. Human hair (plus glow), no tail, no inhuman ears, no additional body parts (bar a penis add-on as a herm). The most non-human I tend to go is add a knot, get Treated (from time to time), long kitty tongue, and glow in the dark eyes.