Strength/Toughness/Willpower Warrior is my favorite build in the game, I think. You're tough as a brick wall, hit like a truck, can heal, nuke shit, and so on. Only real downside is that you're weak to anything that targets magic resist or evasion. You also don't hit quite as hard as a Thief, but you do still hurt.
Throw on Thunderbrand or Ice Warden and you can hold aggro just fine while cracking skulls and shooting lightning. Reaping Blade, Shielding Smite, etc. are all great. Lunar Aegis, Dawnbreak, Rime Veil or Flames Within can make you an absolute monster.
I like to pair it with a two-handed weapon that hits hard and either provides spellpower or otherwise synergizes with spellcasting. Cloudforger, King's Thunderblade, the axe from Elosa's temple (Heart's something, can't remember). Shields, I find, are overkill, and one handed + off hand focus tends to leave your physical damage lacking.
It's a lot of fun.