Ok, here goes.
1. Bad endings: I wish there were no Icky death endings. Instead of having your character dying in a gruesome and painful way, like getting gunned down by turrets or hacked to pieces by robots. A more thematic and fitting bad ending could be presented, death is not really something I look forward to finding in a porn game. That said bad endings are one of my favorite parts of TITS, and I wish that there were more of them. Some basic enemies could and should have eventual bad ends if you lose enough times, it could even be as outlandish and hard to get as having 50 frostwyrm kips.. Red myr venom addict, Lapinara broodmare, Naleen and grey goo spring to mind.
2. The Nursery: There seems like little point to it? More story content, upgrades, Rival/hackers/blackmail, venus pitcher plants containment breach?
3. Kattom: This shady overpriced junk seller is stalking me. I can't seem to find the option of sending him off packing. Such a troubled man selling weapons to backwater natives. I am sure the good Dr. Badger will be grateful to have such a heroic and open minded individual doing some real good instead.
4. Planet Rushers: New planets unexplored teeming with strange and exotic life, yet the few rushers you meet are sampling the local mead. There could be random adventurers out there in the wilderness fighting/exploring/studying. There could be discarded weapons/clothes that hint at some unlucky explorer having meet a bad end.
5. Jack/Jill: I wish they had more story content, I can only assume there is more coming with the new planet. Still wish there was a bit more, they are the main baddie after all. Taunting emails, light sabotage from paying off dock workers to stall you to prank police inspections. There is a lot that could be done to make it seem as if they have to be beaten. The Dane fight on Mengha is a good example of it done right.
^the above is nitpicks and opinion, of which I humbly believe would make the game better.
TITS is a great game and I am grateful for it's existence and continued support/content from the devs