There are different types of Lust damage. An enemy can be resistant or weak to any given type.
Tease: Tease attacks, Bimbolium Emitter. Scales with your Sexiness score.
Psionic: Slut Rays, Light Savicite Maul, etc.
Drug: Milk Squirt, Myr Venom, Royal Shard Bow, ect.
Pheromone; Added to your Tease attacks if you have Pheromone perks. Not sure they deserved the nerf they got.
Weapons scale with Physique/Aim and certain Perks. They can attack more than once/turn.
There's nothing that says you can't do both at the same time, though you'll still want a way to deal with enemies that are resistant/immune to Lust attacks.