They wouldn't need to acknowledge anything. Changing your savefile in a text editor will also generate the warning message.
Yeah, and in either case the devs would rather you
DIDN'T edit your game beyond the few cheats
THEY design and implement. If the main menu had an option "Turn Off Edit Warning Notice At Start-Up", you have three things happen:
1) People would go, "Huh????" and either search the internet on how to edit the game or flood the forums with "HAO DO I EDIT" threads.
2) People would blame the devs when their edited game file breaks because they wanted to do stupid shit like give their Kitsune waifu/PC 999,999,999,999,999,999 tails.
3) Coders would waste hours delving through a posted save file looking for a simple, legit bug when all along the reporter did some stupid shit like give their Kitsune waifu/PC 999,999,999,999,999,999 tails.
And before you come back with some silly reply like, "Yeah, but all the bug reporter has to do is say their game has been edited in their report", I dare you to rethink that argument. I
dare you to give John Q. Public the common sense of a moth.
Oh, and here's the most convincing argument against getting rid of the warning EVAR:
The PTB have already said "never".
EDIT: Here's something else. If there was an option to turn off the pop-up warning, the vast majority of people would miss it because THEY FAIL TO READ SHIT IN A TEXT GAME.
Ironic, ain't it?