Can any content permanently missed?

[SecretSecretSecret]

Anything at all

 

[valk42]

Vaush, if you do not encounter him before doing Arona dungeon

 

[Knife-wielding Crab]

If you close the door on Evelyn and corrupt the beehive you won't be able to finish the dragon lance quest.

 

[SmithEK]

Taking soulbinding will lock you permanently out of Kas romance content.

 

[Savin]

If you don't finish Livrea's quest before finishing Act 1, the quest becomes unavailable.

 

[PalletTown]

List of missable content

Does anyone have a list of content that is missable or that you can be locked out of?

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