I was playing around with some of the different potent and mostly permanent drugs like dumbfuck when it occurred to me that most of these really cool drugs are opt in. Nothing wrong with that, but it also means that the risks they come with aren't really risks anymore. They are the feature you are looking for.
So my idea was (probably as an opt in setting or add-on) what if, when you lose to certain enemies they drug you. Preferably with one of the drugs that has a minor effect on use but a major one on continued use. Like Dumbfuck. Which doesn't do a whole lot till you get fucked a few times while on it. This would possibly also need or make viable a way to remove certain perks like drugfucked. Or just make losing that much more risky for those that have the option turned on.
So my idea was (probably as an opt in setting or add-on) what if, when you lose to certain enemies they drug you. Preferably with one of the drugs that has a minor effect on use but a major one on continued use. Like Dumbfuck. Which doesn't do a whole lot till you get fucked a few times while on it. This would possibly also need or make viable a way to remove certain perks like drugfucked. Or just make losing that much more risky for those that have the option turned on.