W was curious if that actually works. i.e. if you've got a human dick, now with a knot, does that reset it to an ordinary dick.
I checked because the last time I played around with things I ended up in that exact situation (which worked fine for the character) and yeah, Root of Man with a Turgid Mushroom
will result in the knot being removed and you end up with an entirely ordinary human-type penis.
Other combinations can do the same as long as they replace all cock tags, so Cat's Tongue Berry can give you a catfolk penis, Mare's Barley an equine one and so on and they'll remove a knot if you have one.